Notable findings and advances from the past six months
by DANIEL PAUL PEREZ
Chief Science Officer, FSH Society
“Conservation and innovation in the DUX4-family gene network,” from the laboratory of Stephen J. Tapscott at the Fred Hutchinson Cancer Center in Seattle, Washington (Whiddon et al. Nat Genet. 2017 Jun;49(6):935-940. doi: 10.1038/ng.3846. Epub 2017 May 1).
“Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons,” from the laboratory of Bradley R. Cairns at the University of Utah (Hendrickson et al. Nat Genet. 2017 Jun;49(6):925-934).
“DUX-family transcription factors regulate zygotic genome activation in placental mammals,” from the laboratory of Didier Trono at École Polytechnique Fédérale de Lausanne (EPFL), Switzerland (De Iaco et al. Nat Genet. 2017 Jun;49(6):941-945).
This trio of papers in the same issue of Nature Genetics identifies the master role played by DUX4 in early embryogenesis. This body of work is absolutely key and begins to unwrap the normal biological function of DUX4, which is very important to understand if we are to attempt to treat FSHD by suppressing the unwanted negative effects of DUX4.
Read more at the FSH Society.